Exploring the Use of a Guanine-Rich Catalytic DNA for Sulfoxide Preparation

PLoS One. 2015 Jun 12;10(6):e0129695. doi: 10.1371/journal.pone.0129695. eCollection 2015.

Abstract

A guanine-rich DNA oligonucleotide complexed with hemin was used to catalyze controlled oxygen transfer reactions to different sulfides for sulfoxide preparation in the presence of H2O2. Comparable activities were obtained when using fully modified L-DNA. In addition, oligonucleotide immobilization led to an active catalyst which could be successfully recovered and reused without loss of activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • DNA / chemistry*
  • Guanine / chemistry*
  • Hemin / chemistry
  • Hydrogen Peroxide / chemistry
  • Oligodeoxyribonucleotides / chemistry
  • Oxidation-Reduction
  • Safrole / analogs & derivatives*
  • Safrole / chemistry
  • Sulfides / chemistry

Substances

  • Oligodeoxyribonucleotides
  • Sulfides
  • Guanine
  • Hemin
  • DNA
  • Hydrogen Peroxide
  • Safrole
  • sulfoxide

Grants and funding

This work was supported by the Agencia Nacional de Promoción de la Ciencia y la Tecnología (ANPCyT), Argentina, Grant Number: PICT2011-0367. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.