Photoluminescent carbon dots synthesized by microwave treatment for selective image of cancer cells

Xudong Yang; Xue Yang; Zhenyu Li; Shouying Li; Yexuan Han; Yang Chen; Xinyuan Bu; Chunyan Su; Hong Xu; Yingnan Jiang; Quan Lin

doi:10.1016/j.jcis.2015.06.002

Photoluminescent carbon dots synthesized by microwave treatment for selective image of cancer cells

J Colloid Interface Sci. 2015 Oct 15:456:1-6. doi: 10.1016/j.jcis.2015.06.002. Epub 2015 Jun 9.

Authors

Xudong Yang¹, Xue Yang², Zhenyu Li³, Shouying Li⁴, Yexuan Han³, Yang Chen², Xinyuan Bu², Chunyan Su³, Hong Xu⁴, Yingnan Jiang⁵, Quan Lin⁶

Affiliations

¹ School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China. Electronic address: [email protected].
² State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.
³ School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China.
⁴ The First Hospital of Jilin University, Changchun 130021, PR China.
⁵ Lab of Polymer Composites Engineering, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
⁶ State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China. Electronic address: [email protected].

PMID: 26074383
DOI: 10.1016/j.jcis.2015.06.002

Abstract

In this work, a simple, low-cost and one-step microwave approach has been demonstrated for the synthesis of water-soluble carbon dots (C-dots). The average size of the resulting C-dots is about 4 nm. From the photoluminescence (PL) measurements, the C-dots exhibit excellent biocompatibility and intense PL with the high quantum yield (QY) at Ca. 25%. Significantly, the C-dots have excellent biocompatibility and the capacity to specifically target the cells overexpressing the folate receptor (FR). These exciting results indicate the as-prepared C-dots are promising biocompatible probe for cancer diagnosis and treatment.

Keywords: Cancer cells detection; Carbon dots; Fluorescence; Selective image.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemistry
Carbon / chemistry*
Cell Line
Diagnostic Imaging / methods
Fluorescent Dyes / chemistry
Folic Acid / chemistry
HeLa Cells
Humans
Luminescence
Microscopy, Atomic Force
Microscopy, Electron, Transmission
Microwaves*
Nanotechnology / methods
Neoplasms / pathology*
Photochemistry
Quantum Dots
Solvents
Urea / chemistry
Water
X-Ray Diffraction

Substances

Biocompatible Materials
Fluorescent Dyes
Solvents
Water
Carbon
Urea
Folic Acid