Real-Time Three-Dimensional Echocardiography to Assess Right Ventricle Function in Patients with Pulmonary Hypertension

Yidan Li; Yidan Wang; Zhenguo Zhai; Xiaojuan Guo; Yuanhua Yang; Xiuzhang Lu

doi:10.1371/journal.pone.0129557

Real-Time Three-Dimensional Echocardiography to Assess Right Ventricle Function in Patients with Pulmonary Hypertension

PLoS One. 2015 Jun 15;10(6):e0129557. doi: 10.1371/journal.pone.0129557. eCollection 2015.

Authors

Yidan Li¹, Yidan Wang¹, Zhenguo Zhai², Xiaojuan Guo³, Yuanhua Yang², Xiuzhang Lu¹

Affiliations

¹ Department of Echocardiography, Heart Center, Beijing Chao Yang Hospital, Capital Medical University, Beijing, 100020, China.
² Department of Respiratory Medicine, Beijing Chao Yang Hospital, Capital Medical University, Beijing, 100020, China; Beijing Key Laboratory of Respiratory and Pulmonary Circulation, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing, China.
³ Department of Radiology, Beijing Chao Yang Hospital, Capital Medical University, Beijing, 100020, China.

Abstract

Background: The convenience and availability of real-time three-dimensional echocardiography (RT3DE) makes it an attractive candidate for assessing right ventricle function. However, the viability of RT3DE is not conclusive.

Aim of study: This study aims to evaluate RT3DE relative to cardiac magnetic resonance and 2-dimensional echocardiography (2DE) for measuring right ventricular systolic function in patients with pulmonary hypertension.

Methods: Patients with pulmonary hypertension (n = 23) underwent cardiac magnetic resonance, 2DE, and RT3DE. Specifically, 2DE was used to measure the right ventricular index of myocardial performance (RIMP), fractional area change, tricuspid annular plane systolic excursion (TAPSE), and tissue Doppler-derived tricuspid annular systolic velocity (S'). Cardiac magnetic resonance and RT3DE were used to measure right ventricular end-diastolic volume (RVEDV) and end-systolic volume (RVESV). The right ventricular ejection fraction (RVEF) was calculated.

Results: Regarding the measurements taken by 2DE, RVEF positively correlated with fractional area change (r = 0.595, P = 0.003) and S'(r = 0.489, P = 0.018), and negatively correlated with RIMP (r = -0.745, P = 0.000). There was no association between RVEF and TAPSE (r = -0.029, P = 0.896). There existed a close correlation between the values of RVEDV, RVESV, and RVEF as measured by RT3DE and CMR respectively (P<0.001); Bland-Altmanan analyses showed good agreement between them.

Conclusion: RT3DE was a viable method for noninvasive, accurate assessment of right ventricular systolic function in patients with pulmonary hypertension.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Echocardiography
Echocardiography, Four-Dimensional*
Female
Humans
Hypertension, Pulmonary / diagnostic imaging*
Hypertension, Pulmonary / physiopathology*
Magnetic Resonance Imaging
Male
Middle Aged
Reproducibility of Results
Ventricular Function, Right*

Grants and funding

This study was supported by the National Natural Science Foundation of China (Grant No. 81401420); the Fund of Beijing excellent talent training Plan (Grant No. 2013D003034000012), and Fund of clinical application of capital project (Grant No. Z141107002514074). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.