A fox circovirus was identified in serum samples from foxes with unexplained neurologic signs by using viral metagenomics. Fox circovirus nucleic acid was localized in histological lesions of the cerebrum by in situ hybridization. Viruses from the family Circoviridae may have neurologic tropism more commonly than previously anticipated.
Keywords: United Kingdom; brain; cerebrospinal fluid; circovirus; cyclovirus; encephalitis; foxes; meningoencephalitis; neurologic disease; random amplification; serum; viruses.