Mortality predictors of epilepsy and epileptic seizures among hospitalized elderly

Arq Neuropsiquiatr. 2015 Jun;73(6):510-5. doi: 10.1590/0004-282X20150043.

Abstract

Epilepsy and epileptic seizures are common brain disorders in the elderly and are associated with increased mortality that may be ascribed to the underlying disease or epilepsy-related causes.

Objective: To describe mortality predictors of epilepsy and epileptic seizures in elderly inpatients.

Method: Retrospective analysis was performed on hospitalized elderly who had epilepsy or epileptic seizures, from January 2009 to December 2010. One hundred and twenty patients were enrolled.

Results: The most common etiology was ischemic stroke (37%), followed by neoplasias (13%), hemorrhagic stroke (12%), dementias (11.4%) and metabolic disturbances (5.5%). In a univariate analysis, disease duration (p = 0.04), status epilepticus (p < 0.001) and metabolic etiology (p = 0.005) were associated with mortality. However after adjustment by logistic regression, only status epilepticus remained an independent predictor of death (odds ratio = 13; 95%CI = 2.3 to 72; p = 0.004).

Conclusion: In this study status epilepticus was an independent risk factor for death during hospitalization.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Brain Ischemia / complications
  • Brain Ischemia / mortality
  • Brazil / epidemiology
  • Epidemiologic Methods
  • Epilepsy / etiology*
  • Epilepsy / mortality*
  • Female
  • Hospital Mortality*
  • Hospitalization
  • Humans
  • Male
  • Metabolic Diseases / complications
  • Metabolic Diseases / mortality
  • Risk Factors
  • Stroke / complications
  • Stroke / mortality