Umbilical cord blood transplantation supplemented with the infusion of mesenchymal stem cell for an adolescent patient with severe aplastic anemia: a case report and review of literature

Chengxin Luan; Runzhe Chen; Baoan Chen; Jiahua Ding; Ming Ni

doi:10.2147/PPA.S81509

Umbilical cord blood transplantation supplemented with the infusion of mesenchymal stem cell for an adolescent patient with severe aplastic anemia: a case report and review of literature

Patient Prefer Adherence. 2015 Jun 11:9:759-65. doi: 10.2147/PPA.S81509. eCollection 2015.

Authors

Chengxin Luan¹, Runzhe Chen¹, Baoan Chen¹, Jiahua Ding¹, Ming Ni¹

Affiliation

¹ Department of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province, People's Republic of China.

Abstract

Delayed hematopoietic recovery and increased rate of engraftment failure limit the use of umbilical cord blood transplantation (UCBT). We describe a case of severe aplastic anemia treated by UCBT combined with mesenchymal stem cells. Our case reveals that infusing mesenchymal stem cells early (about 40 days) after UCBT may promote hematopoietic recovery. This experience will guide clinical scientists, especially hematologists, to deal with similar situations and encourage them to widen this strategy.

Keywords: aplastic anemia; cord blood transplantation; mesenchymal stem cell.

Publication types

Case Reports