Bending Forks and Wagging Dogs--It's about the DNA 3' Tail

Susan E Tsutakawa; John A Tainer

doi:10.1016/j.molcel.2015.06.005

Bending Forks and Wagging Dogs--It's about the DNA 3' Tail

Mol Cell. 2015 Jun 18;58(6):972-3. doi: 10.1016/j.molcel.2015.06.005.

Authors

Susan E Tsutakawa¹, John A Tainer²

Affiliations

¹ Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
² Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: [email protected].

Abstract

Protecting, reversing, and remodeling stalled replication forks are critical to genome stability and require coordinating DNA replication, remodeling, and repair. In this issue, Kile et al. (2015) find that unexpected HLTF specificity for DNA's 3'-hydroxyl tail helps control these biological functions.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

DNA / metabolism*
DNA Replication*
DNA-Binding Proteins / metabolism*
Humans
Transcription Factors / metabolism*

Substances

DNA-Binding Proteins
Transcription Factors
DNA

Abstract

Publication types

MeSH terms

Substances

Grants and funding