Limited value of angiogenic factors in obese women

Priscille Loire; Eric Vicaut; Philippe Cruaud; Nathalie Charnaux; Lionel Carbillon

doi:10.1016/j.preghy.2012.06.001

Limited value of angiogenic factors in obese women

Pregnancy Hypertens. 2012 Oct;2(4):368-70. doi: 10.1016/j.preghy.2012.06.001. Epub 2012 Jul 13.

Authors

Priscille Loire¹, Eric Vicaut², Philippe Cruaud³, Nathalie Charnaux⁴, Lionel Carbillon⁵

Affiliations

¹ AP-HP, Paris 13 University, Department of Obstetrics and Gynecology, Hôpital Jean Verdier, France.
² AP-HP, Paris 7 University, Clinical Research Unit, Hôpital Fernand Widal, France.
³ AP-HP, Department of Biology, Hôpital Jean Verdier, France.
⁴ AP-HP, Paris 13 University, Department of Biochemistry, Hôpital Jean Verdier, France.
⁵ AP-HP, Paris 13 University, Department of Obstetrics and Gynecology, Hôpital Jean Verdier, France. Electronic address: [email protected].

PMID: 26105604
DOI: 10.1016/j.preghy.2012.06.001

Abstract

We performed a case-control study assessing the predictive value of sVEGFR and PlGF for preeclampsia in a population with high obesity prevalence. Body mass index and circulating mean concentrations of sVEGFR and PlGF were significantly higher in preeclamptic women. However, a two variable model associating sVEGFR and PlGF dosages was not better than the model including only age and BMI. When the prevalence of obesity is high, the extra benefit of the dosages of angiogenic factors appears to be of limited value.

Keywords: BMI; Obesity; Overweight; PlGF; Preeclampsia; SFlt-1; sVEGFR.