A red-emitting ratiometric fluorescent probe based on a benzophosphole P-oxide scaffold for the detection of intracellular sodium ions

Chem Commun (Camb). 2015 Jul 28;51(59):11880-3. doi: 10.1039/c5cc03547c.

Abstract

We disclose the development of a ratiometric fluorescent probe based on a benzophosphole P-oxide and its application for the detection of intracellular Na(+) ions. Excitation by visible light induced red emission from this probe in water, which was subjected to a hypsochromic shift upon complexation with Na(+). Based on this change, a ratiometric analysis enabled us to visualise changes in the Na(+) concentration in living mammalian cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclic P-Oxides / chemical synthesis
  • Cyclic P-Oxides / chemistry*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Ions / analysis
  • Molecular Structure
  • Oxides / chemical synthesis
  • Oxides / chemistry*
  • Sodium / analysis*

Substances

  • Cyclic P-Oxides
  • Fluorescent Dyes
  • Ions
  • Oxides
  • Sodium