Biotransformation and stability of antibody-drug conjugates: payload metabolism and linker cleavage delineation

Vangipuram S Rangan; Heather Myler; Alexander Kozhich; Jian Wang; Renee Randazzo; Shrikant Deshpande

doi:10.4155/bio.15.50

Biotransformation and stability of antibody-drug conjugates: payload metabolism and linker cleavage delineation

Bioanalysis. 2015;7(11):1319-23. doi: 10.4155/bio.15.50.

Authors

Vangipuram S Rangan¹, Heather Myler², Alexander Kozhich², Jian Wang³, Renee Randazzo⁴, Shrikant Deshpande¹

Affiliations

¹ Biologics Discovery California, Bristol-Myers Squibb, Redwood City, CA 94063, USA.
² Bioanalytical Sciences-Biologics, Bristol-Myers Squibb, Lawrenceville, NJ, USA.
³ Bioanalytical Sciences-LCMS, Bristol-Myers Squibb, Lawrenceville, NJ, USA.
⁴ Global Manufacturing & Supply/Biologics Development & Operations, Hopewell, NJ, USA.

PMID: 26110704
DOI: 10.4155/bio.15.50

No abstract available

Keywords: active antibody–drug conjugates; bioanalytical assay; biotransformation; conjugated antibody; conjugated payload; drug to antibody ratio; linker cleavage; unconjugated payload.

MeSH terms

Animals
Biotransformation
Chemistry Techniques, Analytical / methods
Drug Stability
Humans
Immunoconjugates / chemistry
Immunoconjugates / metabolism*
Pharmaceutical Preparations / chemistry
Pharmaceutical Preparations / metabolism*
Protein Stability

Substances

Immunoconjugates
Pharmaceutical Preparations