Copycat innate lymphoid cells dampen gut inflammation

Cell Res. 2015 Sep;25(9):991-2. doi: 10.1038/cr.2015.79. Epub 2015 Jun 26.

Abstract

The mechanisms whereby the gut mucosa tolerates trillions of commensal bacteria without developing inflammation remain poorly understood. A recent Science article reveals that gut innate lymphoid cells constrain inflammatory T cell responses to commensal bacteria by adopting a strategy usually deployed by thymic epithelial cells to negatively select self-reactive T cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bacteria / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • Colon / microbiology*
  • Female
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Immunity, Innate*
  • Inflammatory Bowel Diseases / microbiology*
  • Male

Substances

  • Histocompatibility Antigens Class II