Distinct molecular abnormalities underlie unique clinical features of essential thrombocythemia in children

Leukemia. 2016 Mar;30(3):746-9. doi: 10.1038/leu.2015.167. Epub 2015 Jun 29.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alleles
  • Calreticulin / genetics*
  • Calreticulin / metabolism
  • Case-Control Studies
  • Cell Proliferation
  • Child
  • Child, Preschool
  • Female
  • Gene Expression
  • Gene Frequency
  • Haplotypes
  • Humans
  • Janus Kinase 2 / genetics*
  • Janus Kinase 2 / metabolism
  • Male
  • Megakaryocytes / metabolism
  • Megakaryocytes / pathology
  • Mutation*
  • Receptors, Thrombopoietin / genetics*
  • Receptors, Thrombopoietin / metabolism
  • Sequence Analysis, DNA
  • Thrombocythemia, Essential / diagnosis*
  • Thrombocythemia, Essential / genetics*
  • Thrombocythemia, Essential / metabolism
  • Thrombocythemia, Essential / pathology

Substances

  • CALR protein, human
  • Calreticulin
  • Receptors, Thrombopoietin
  • MPL protein, human
  • JAK2 protein, human
  • Janus Kinase 2