Targeting the inflammasome in rheumatic diseases

Sara S McCoy; Jasmine Stannard; J Michelle Kahlenberg

doi:10.1016/j.trsl.2015.06.006

Targeting the inflammasome in rheumatic diseases

Transl Res. 2016 Jan;167(1):125-37. doi: 10.1016/j.trsl.2015.06.006. Epub 2015 Jun 11.

Authors

Sara S McCoy¹, Jasmine Stannard², J Michelle Kahlenberg³

Affiliations

¹ Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich.
² Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich; Division of Rheumatology, Department of Pediatrics, University of Michigan, Ann Arbor, Mich.
³ Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich. Electronic address: [email protected].

Abstract

Activation of the inflammasome, a protein complex responsible for many cellular functions, including the activation of the proinflammatory cytokines interleukin (IL)-1β and IL-18, has been identified as a key participant in many rheumatic diseases including autoimmune, inflammatory, and autoinflammatory syndromes. This review will discuss the recent advances in understanding the role of this complex in various rheumatic diseases. Furthermore, it will focus on available therapies, which directly and indirectly target the inflammasome and its downstream cytokines to quiet inflammation and possibly dampen autoimmune processes.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Cytokines / metabolism
Drug Delivery Systems*
Humans
Inflammasomes / drug effects*
Inflammation / metabolism
Rheumatic Diseases / drug therapy*
Rheumatic Diseases / immunology
Signal Transduction

Substances

Cytokines
Inflammasomes

Abstract

Publication types

MeSH terms

Substances

Grants and funding