Electrochemotherapy as a new approach on pancreatic cancer and on liver metastases

Salvatore Tafuto; Claudia von Arx; Chiara De Divitiis; Claire Tracey Maura; Raffaele Palaia; Vittorio Albino; Roberta Fusco; Massimo Membrini; Antonella Petrillo; Vincenza Granata; Francesco Izzo; ENETS Center of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy)

doi:10.1016/j.ijsu.2015.04.095

Electrochemotherapy as a new approach on pancreatic cancer and on liver metastases

Int J Surg. 2015 Sep:21 Suppl 1:S78-82. doi: 10.1016/j.ijsu.2015.04.095. Epub 2015 Jun 27.

Affiliations

¹ Department of Abdominal Oncology, Division of Medical Oncology, NCI "Fondazione G. Pascale", Naples, Italy. Electronic address: [email protected].
² Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy. Electronic address: [email protected].
³ Department of Abdominal Oncology, Division of Medical Oncology, NCI "Fondazione G. Pascale", Naples, Italy. Electronic address: [email protected].
⁴ Department of Abdominal Oncology, Division of Medical Oncology, NCI "Fondazione G. Pascale", Naples, Italy. Electronic address: [email protected].
⁵ Department of Abdominal Oncology, Division of Surgical Oncology, NCI "Fondazione G. Pascale", Naples, Italy. Electronic address: [email protected].
⁶ Department of Abdominal Oncology, Division of Surgical Oncology, NCI "Fondazione G. Pascale", Naples, Italy. Electronic address: [email protected].
⁷ Department of Diagnostic Imaging, NCI of Naples, "Fondazione G. Pascale", Naples, Italy. Electronic address: [email protected].
⁸ Department of Abdominal Oncology, Division of Medical Oncology, NCI "Fondazione G. Pascale", Naples, Italy. Electronic address: [email protected].
⁹ Department of Diagnostic Imaging, NCI of Naples, "Fondazione G. Pascale", Naples, Italy. Electronic address: [email protected].
¹⁰ Department of Diagnostic Imaging, NCI of Naples, "Fondazione G. Pascale", Naples, Italy. Electronic address: [email protected].
¹¹ Department of Abdominal Oncology, Division of Surgical Oncology, NCI "Fondazione G. Pascale", Naples, Italy. Electronic address: [email protected].

PMID: 26123385
DOI: 10.1016/j.ijsu.2015.04.095

Abstract

Electrochemotherapy is a local non-thermal treatment for cancer ablation. Currently, many studies and case report have investigated the differences in effectiveness of electrochemotherapy with respect to tumor type, chemotherapeutic drug, and route of drug administration. ESOPE trial validated standard operating procedures [SOP] for ECT using the Cliniporator device and demonstrated that ECT is a simple, highly efficacious, and cost-effective treatment of cutaneous and subcutaneous nodules from different primary tumors for cutaneous or superficial lesions. This review has the purpose to summarize current knowledge about clinical effectiveness of electrochemotherapy and future prospects regarding its use on pancreatic cancer and liver metastasis not only.

Keywords: Electrochemotherapy; Electroporation; Liver metastasis; Neuroendocrine tumor; Pancreatic cancer.

Publication types

Review

MeSH terms

Antineoplastic Agents / administration & dosage
Antineoplastic Agents / therapeutic use*
Electrochemotherapy / methods*
Humans
Liver Neoplasms / drug therapy*
Liver Neoplasms / secondary
Pancreatic Neoplasms / drug therapy*
Treatment Outcome

Substances

Antineoplastic Agents