Total Synthesis of (+)-3-Demethoxyerythratidinone and (+)-Erysotramidine via the Oxidative Amidation of a Phenol

Marco Paladino; Joshua Zaifman; Marco A Ciufolini

doi:10.1021/acs.orglett.5b01423

Total Synthesis of (+)-3-Demethoxyerythratidinone and (+)-Erysotramidine via the Oxidative Amidation of a Phenol

Org Lett. 2015 Jul 17;17(14):3422-5. doi: 10.1021/acs.orglett.5b01423. Epub 2015 Jun 30.

Authors

Marco Paladino¹, Joshua Zaifman¹, Marco A Ciufolini¹

Affiliation

¹ Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.

PMID: 26125652
DOI: 10.1021/acs.orglett.5b01423

Abstract

Oxidative amidation chemistry provides a unified route to aromatic Erythrina alkaloids through a sequence that illustrates new principles and improved conditions to effect a crucial eliminative Curtius-Schmidt rearrangement.