Cilia: Organelles at the Heart of Heart Disease

Vijay Narasimhan; Sudipto Roy

doi:10.1016/j.cub.2015.05.005

Cilia: Organelles at the Heart of Heart Disease

Curr Biol. 2015 Jun 29;25(13):R559-62. doi: 10.1016/j.cub.2015.05.005.

Authors

Vijay Narasimhan¹, Sudipto Roy²

Affiliations

¹ Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673.
² Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore; Department of Pediatrics, National University of Singapore, 1E Kent Ridge Drive, Singapore. Electronic address: [email protected].

PMID: 26126281
DOI: 10.1016/j.cub.2015.05.005

Abstract

Genetic disorders, such as heterotaxy, first provided a link between cilia and developmental heart defects. Now, a genetic screen in mice shows that ciliary dysfunction may indeed be the major contributing factor in the etiology of congenital heart disease.

MeSH terms

Animals
Ciliary Motility Disorders / complications*
DNA Mutational Analysis
Heart Defects, Congenital / etiology*
Heart Defects, Congenital / genetics
Heart Defects, Congenital / pathology*
Mice
Models, Biological*
Protein Interaction Mapping
Signal Transduction / physiology*