We studied effect of therapy with fixed combination of lercanidipine and enalapril on 24-hour blood pressure (BP) profile in 34 elderly patients (mean age 76.4±5.2 years, 14 men, 20 women) with degree I hypertension. After clinical examination patients were given lercanidipine/ enalapril combination (10/10 mg/day). The dose was increased to 10+20 mg/day when necessary. Assessment of efficacy was conducted on Rate of achievement of target BP [systolic (S) BP <150 mm HG, diastolic (D) BP<90 mmHg] and dynamics of parameters of 24-hour BP profile. Re-examinations were carried out on weeks 4.8 and 12 of treatment. Administration of lercanidipine/enalapril combination was associated with mean 24-hour SBP and DBP lowering (by15.3 and 8.7%, respectively). Diurnal and nocturnal SBP/DBP decreased by 15.7/ 9.2 and 14.1/8.5%, respectively. BP variability also significantly decreased: of diurnal SBP/DBP - 3.8/4.1 mm Hg (21.7/24.7%), of nocturnal SBP/DBP - 2.8/4.1 mm Hg (17.9/19.6%). There was no significant dynamics of the heart rate. Therapy with lercanidipine/enalapril combination for 12 weeks did not lead to the deterioration of carbohydrate, lipid metabolism, or renal function. Thus using lercanidipine/ enalapril combination we observed pronounced antihypertensive effect which consisted in decrease of mean BP and normalization of BP circadian rhythm of blood pressure.