The synthesis of new potential photosensitizers. 1. Mono-carboxylic acid derivatives of tetraphenylporphyrin

Grzegorz Zięba; Marcin Rojkiewicz; Violetta Kozik; Krystyna Jarzembek; Anna Jarczyk; Aleksander Sochanik; Piotr Kuś

doi:10.1007/s00706-011-0586-3

The synthesis of new potential photosensitizers. 1. Mono-carboxylic acid derivatives of tetraphenylporphyrin

Monatsh Chem. 2012;143(1):153-159. doi: 10.1007/s00706-011-0586-3. Epub 2011 Aug 24.

Authors

Grzegorz Zięba¹, Marcin Rojkiewicz¹, Violetta Kozik¹, Krystyna Jarzembek¹, Anna Jarczyk¹, Aleksander Sochanik², Piotr Kuś¹

Affiliations

¹ Department of Chemistry, University of Silesia, 9, Szkolna Street, 40-006 Katowice, Poland.
² Department of Molecular Biology, Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, 44-100 Gliwice, Poland.

Abstract

Abstract: A series of mono-alkylcarboxylic acid derivatives of tetraphenylporphyrin have been prepared. All the porphyrins were completely characterized by use of mass, ¹H NMR, UV-visible, and fluorescence spectroscopy. Experimental log P were determined by use of reversed-phase thin-layer chromatography with use of log P_Rekker. These porphyrins are potential photosensitizers in photodynamic therapy.

Keywords: Fluorescence spectroscopy; Hydrophobicity; Porphyrins; Sensitizers.