A highlight from the LUPUS 2014 meeting: eight great ideas

Jill P Buyon; Phillip Cohen; Joan T Merrill; Gary Gilkeson; Mariana Kaplan; Judith James; W Joseph McCune; Sasha Bernatsky; Keith Elkon

doi:10.1136/lupus-2015-000087

A highlight from the LUPUS 2014 meeting: eight great ideas

Lupus Sci Med. 2015 Jun 30;2(1):e000087. doi: 10.1136/lupus-2015-000087. eCollection 2015.

Authors

Jill P Buyon¹, Phillip Cohen², Joan T Merrill³, Gary Gilkeson⁴, Mariana Kaplan⁵, Judith James⁶, W Joseph McCune⁷, Sasha Bernatsky⁸, Keith Elkon⁹

Affiliations

¹ Division of Rheumatology, Department of Medicine , NYU School of Medicine , New York, New York , USA.
² Departments of Medicine, Section of Rheumatology, Department of Microbiology and Immunology , Temple University School of Medicine , Philadelphia, Pennsylvania , USA.
³ Clinical Pharmacology Research Program , Oklahoma Medical Research Foundation , Oklahoma City, Oklahoma , USA.
⁴ Department of Medicine , Medical University of South Carolina, Medical Research Service, Ralph H. Johnson VAMC , Charleston, South Carolina , USA.
⁵ Systemic Autoimmunity Branch , National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland , USA.
⁶ Department of Arthritis and Clinical Immunology , Oklahoma Medical Research Foundation , Oklahoma City, Oklahoma , USA.
⁷ Department of Internal Medicine , University of Michigan Health System , Ann Arbor, Michigan , USA.
⁸ Divisions of Rheumatology and Clinical Epidemiology , McGill University Health Centre , Montreal, Quebec , Canada.
⁹ Departments of Medicine and Immunology , University of Washington , Seattle, Washington , USA.

Abstract

This review describes eight 'great ideas' regarding bench-to-bedside considerations in systemic lupus erythematosus (SLE) presented at the second international LUPUS meeting in Quebec, September 2014. The topics included: correcting the impaired clearance of apoptotic fragments; optimisation of clinical trial design: the PERFECT (Pre Evaluation Reducing Frighteningly Elevated Coverable Targets) study; lipidomics and metabolomics in SLE; importance of the inflammasome; identification and treatment of asymptomatic autoimmunity: prevention of SLE; combining low doses of hydroxychloroquine and quinacrine for long-term maintenance therapy of SLE; reducing emergency room visits and the critical relevance of the autoantigen.

Keywords: Autoimmunity; Disease Activity; Inflammation; Lupus Nephritis; Systemic Lupus Erythematosus.

Publication types

Review

Abstract

Publication types

Grants and funding