There are two mechanisms of mitral regurgitation formation in postmyocardial infarction patients: local myocardial remodeling with changing of mitral chord tethering, and global myocardial remodeling with dilatation of mitral ring. Analysis of data of the "Register of provided coronary angiography" showed that the first mechanism in preponderant in men, and the second - in women. Factors found to be associated with chronic moderate and pronounced mitral regurgitation in men and women after myocardial infarction are presented in this article.