Cancer: A dendritic-cell brake on antitumour immunity

Nature. 2015 Jul 16;523(7560):294-5. doi: 10.1038/523294a.

Abstract

Activation of a cellular stress response and the transcription factor XBP1 in dendritic cells has now been shown to limit the cells' ability to stimulate antitumour immune responses in a mouse model of ovarian cancer.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism*
  • Dendritic Cells / pathology*
  • Endoplasmic Reticulum Stress*
  • Female
  • Humans
  • Ovarian Neoplasms / immunology*
  • Ovarian Neoplasms / pathology*
  • Transcription Factors / metabolism*

Substances

  • DNA-Binding Proteins
  • Transcription Factors