Loss of Vancomycin-Resistant Enterococcus Fecal Dominance in an Organ Transplant Patient With Clostridium difficile Colitis After Fecal Microbiota Transplant

Joshua Stripling; Ranjit Kumar; John W Baddley; Anoma Nellore; Paula Dixon; Donna Howard; Travis Ptacek; Elliot J Lefkowitz; Jose A Tallaj; William H Benjamin Jr; Casey D Morrow; J Martin Rodriguez

doi:10.1093/ofid/ofv078

Loss of Vancomycin-Resistant Enterococcus Fecal Dominance in an Organ Transplant Patient With Clostridium difficile Colitis After Fecal Microbiota Transplant

Open Forum Infect Dis. 2015 Jun 3;2(2):ofv078. doi: 10.1093/ofid/ofv078. eCollection 2015 Apr.

Authors

Affiliations

¹ Division of Infectious Diseases, Department of Medicine.
² Center for Clinical and Translational Sciences.
³ Departments of Pathology.
⁴ Microbiology.
⁵ Center for Clinical and Translational Sciences ; Microbiology.
⁶ Division of Cardiology, Department of Medicine.
⁷ Department of Cell, Developmental and Integrative Biology , University of Alabama at Birmingham.

Abstract

We report the use of fecal microbiota transplantation in a single heart-kidney transplant recipient with recurrent Clostridium difficile, vancomycin-resistant Enterococcus (VRE) fecal dominance, and recurrent VRE infections. Fecal microbiota transplantation resulted in the reconstruction of a diverse microbiota with (1) reduced relative abundance of C difficile and VRE and (2) positive clinical outcome.

Keywords: C difficile; VRE; fecal microbiota transplant; gut microbiome; vancomycin-resistant Enterococcus.

Abstract

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