Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemotherapy-Synergized Tumor Ablation

Aijun Zhu; Ke Miao; Yibin Deng; Hengte Ke; Hui He; Tao Yang; Miao Guo; Yanli Li; Zhengqing Guo; Yangyun Wang; Xiangliang Yang; Youliang Zhao; Huabing Chen

doi:10.1021/acsnano.5b02843

Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemotherapy-Synergized Tumor Ablation

ACS Nano. 2015 Aug 25;9(8):7874-85. doi: 10.1021/acsnano.5b02843. Epub 2015 Jul 27.

Authors

Aijun Zhu¹, Ke Miao², Yibin Deng¹, Hengte Ke¹, Hui He¹, Tao Yang¹, Miao Guo¹, Yanli Li¹, Zhengqing Guo³, Yangyun Wang³, Xiangliang Yang⁴, Youliang Zhao², Huabing Chen^{1

3}

Affiliations

¹ Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University , Suzhou, Jiangsu 215123, China.
² Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, and College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou , Jiangsu 215123, China.
³ School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and School of Radiation Medicine and Protection, Soochow University , Suzhou, Jiangsu 215123, China.
⁴ College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan 430074, China.

PMID: 26181349
DOI: 10.1021/acsnano.5b02843

Abstract

Smart nanocarriers are of particular interest as nanoscale vehicles of imaging and therapeutic agents in the field of theranostics. Herein, we report dually pH/reduction-responsive terpolymeric vesicles with monodispersive size distribution, which are constructed by assembling acetal- and disulfide-functionalized star terpolymer with near-infrared cyanine dye and anticancer drug. The vesicular nanostructure exhibits multiple theranostic features including on-demand drug releases responding to pH/reduction stimuli, enhanced photothermal conversion efficiency of cyanine dye, and efficient drug translocation from lysosomes to cytoplasma, as well as preferable cellular uptakes and biodistribution. These multiple theranostic features result in ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation. The dually stimuli-responsive vesicles represent a versatile theranostic approach for enhanced cancer imaging and therapy.

Keywords: cancer imaging; photothermal therapy; stimuli-responsive release; synergistic effect; vesicles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylic Resins / chemistry
Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Doxorubicin / chemistry
Doxorubicin / pharmacology*
Drug Carriers*
Drug Liberation
Female
Fluorescent Dyes / chemistry
Fluorescent Dyes / pharmacology
Hydrogen-Ion Concentration
Hyperthermia, Induced / methods
Indocyanine Green / chemistry
Indocyanine Green / pharmacology*
Mammary Neoplasms, Animal / diagnosis
Mammary Neoplasms, Animal / pathology
Mammary Neoplasms, Animal / therapy*
Mice
Mice, Nude
Nanostructures / chemistry
Nanostructures / therapeutic use*
Nanostructures / ultrastructure
Optical Imaging / methods*
Oxidation-Reduction
Particle Size
Photochemical Processes
Polyesters / chemistry
Polyethylene Glycols / chemistry
Singlet Oxygen / metabolism
Theranostic Nanomedicine / methods*

Substances

Acrylic Resins
Antineoplastic Agents
Drug Carriers
Fluorescent Dyes
Polyesters
Singlet Oxygen
polycaprolactone
poly-N-isopropylacrylamide
Polyethylene Glycols
Doxorubicin
Indocyanine Green