DNA damage and repair regulate neuronal gene expression

Yijing Su; Guo-li Ming; Hongjun Song

doi:10.1038/cr.2015.85

DNA damage and repair regulate neuronal gene expression

Cell Res. 2015 Sep;25(9):993-4. doi: 10.1038/cr.2015.85. Epub 2015 Jul 17.

Authors

Yijing Su^{1

2}, Guo-li Ming^{1

2

3

4}, Hongjun Song^{1

2

3}

Affiliations

¹ Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
³ The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁴ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Neuronal activity-induced gene expression is crucial for the development and plasticity of the brain and for learning and memory. In a recent study published in Cell, Madabhushi et al. report that neuronal activity triggers the formation of DNA double-strand breaks on promoters of early response genes, which in turn controls their expression in neurons.

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MeSH terms

Animals
DNA Breaks, Double-Stranded*
Neurons / metabolism*