Immunodeficiency-associated viral oncogenesis

A Pierangeli; G Antonelli; G Gentile

doi:10.1016/j.cmi.2015.07.009

Immunodeficiency-associated viral oncogenesis

Clin Microbiol Infect. 2015 Nov;21(11):975-83. doi: 10.1016/j.cmi.2015.07.009. Epub 2015 Jul 18.

Authors

A Pierangeli¹, G Antonelli¹, G Gentile²

Affiliations

¹ Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Rome, Italy.
² Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy. Electronic address: [email protected].

PMID: 26197213
DOI: 10.1016/j.cmi.2015.07.009

Abstract

Several viruses with different replication mechanisms contribute to oncogenesis by both direct and indirect mechanisms in immunosuppressed subjects after solid organ transplantation, after allogeneic stem cell transplantation, or with human immunodeficiency virus (HIV) infection. Epstein-Barr virus (EBV), human papillomavirus (HPV), Kaposi sarcoma herpesvirus (KSHV), human T-cell lymphotropic virus type 1 (HTLV-1) and Merkel cell polyoma virus (MCV) are the main viruses associated with the development of cancer in immunosuppressed patients. Besides being a main cause of immunodeficiency, HIV1 has a direct pro-oncogenic effect. In this review, we provide an update on the association between the condition of acquired immunodeficiency and cancer risk, specifically addressing the contributions to oncogenesis of HPV, MCV, KSHV, HTLV-1, and EBV.

Keywords: Carcinogenesis; HIV; immunodeficiency; transplantation; viral oncogenesis.

Publication types

Review

MeSH terms

Carcinogenesis*
Humans
Immunocompromised Host*
Neoplasms / epidemiology*
Neoplasms / pathology*
Oncogenic Viruses / growth & development*
Virus Diseases / complications*
Virus Diseases / virology*