miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof

Thomas B Huffaker; Ryan M O'Connell

doi:10.1016/j.immuni.2015.06.020

miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof

Immunity. 2015 Jul 21;43(1):3-4. doi: 10.1016/j.immuni.2015.06.020.

Authors

Thomas B Huffaker¹, Ryan M O'Connell²

Affiliations

¹ Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
² Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: [email protected].

PMID: 26200005
DOI: 10.1016/j.immuni.2015.06.020

Abstract

The importance of individual target genes for miRNA activity has been difficult to establish. In this issue of Immunity, Lu et al. (2015) disrupt the miR-155 binding site in the SOCS1 3' UTR in the mouse germline and show that this axis is important for T and NK cell function.

Publication types

Comment

MeSH terms

Animals
CD8-Positive T-Lymphocytes / immunology*
Killer Cells, Natural / immunology*
MicroRNAs / genetics*
Suppressor of Cytokine Signaling Proteins / genetics*
T-Lymphocytes, Regulatory / immunology*

Substances

MicroRNAs
Suppressor of Cytokine Signaling Proteins