Background: The consequences of aneurysmal subarachnoid hemorrhage (aSAH) are lifelong and fatal. Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) play an important role in the regulation of vascular structure and function. Our study examined the association between angiopoietin levels and functional outcomes among aSAH patients.
Methods: We enrolled 37 aSAH patients and 39 controls (matched on age and sex) at the Department of Neurosurgery in Tianjin Medical University General Hospital. Serum Ang-1, Ang-2, and Tie-2 levels were collected at 8, 24, and 72 hours post-hemorrhage. After a 3-month follow-up period, patient outcomes were evaluated using the Glasgow Outcome Score (GOS). Logistic regression examined the association between angiopoietin levels and outcomes (good [GOS: 4-5] vs. poor [GOS: 1-3]).
Results: aSAH patients had higher levels of Ang-1 at 8 hours post-hemorrhage compared to controls. Among aSAH patients, Ang-1 levels at 8, 24, and 72 hours post-hemorrhage were higher among patients with a good outcome. Compared to patients with low Ang-1 levels, high Ang-1 levels at 72 hours post-hemorrhage were associated with a good outcome.
Conclusions: High Ang-1 levels were associated with a good functional outcome after aSAH. Abnormal angiopoietin levels may disrupt the blood-brain barrier and contribute to functional outcomes in aSAH patients.
Keywords: Aneurysm; Angiopoietin; Clinical trial; Early brain injury; Subarachnoid hemorrhage.
Copyright © 2015. Published by Elsevier B.V.