On Molecular Classification of Bladder Cancer: Out of One, Many

Mattias Aine; Pontus Eriksson; Fredrik Liedberg; Mattias Höglund; Gottfrid Sjödahl

doi:10.1016/j.eururo.2015.07.021

On Molecular Classification of Bladder Cancer: Out of One, Many

Eur Urol. 2015 Dec;68(6):921-3. doi: 10.1016/j.eururo.2015.07.021. Epub 2015 Jul 26.

Authors

Mattias Aine¹, Pontus Eriksson¹, Fredrik Liedberg², Mattias Höglund¹, Gottfrid Sjödahl³

Affiliations

¹ Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
² Division of Urological Research, Department of Translational Medicine, Lund University, Malmö, Sweden.
³ Division of Urological Research, Department of Translational Medicine, Lund University, Malmö, Sweden. Electronic address: [email protected].

PMID: 26215606
DOI: 10.1016/j.eururo.2015.07.021

Abstract

Comparative analysis showed that bladder cancer classification systems identify overlapping subtypes but at different levels. Muscle-invasive bladder cancer shows remarkable heterogeneity, and six subtypes were identified that differ in transcriptional networks, marker profiles, and expression of actionable targets.

MeSH terms

Gene Expression Regulation, Neoplastic
Humans
Urinary Bladder Neoplasms / classification*
Urinary Bladder Neoplasms / genetics*