Synthesis of deuterium-labeled hydroxybupropion

J Labelled Comp Radiopharm. 2015 Aug;58(10):411-3. doi: 10.1002/jlcr.3314. Epub 2015 Jul 28.

Abstract

This paper describes the synthesis of deuterium-labeled hydroxybupropion. Mass spectrometry analysis of the compound revealed over 98% deuterium enrichment.

Keywords: bupropion; deuterium-labeled; hydroxybupropion; metabolite; synthesis.

MeSH terms

  • Antidepressive Agents, Second-Generation / chemical synthesis*
  • Bupropion / analogs & derivatives*
  • Bupropion / chemical synthesis
  • Deuterium / chemistry*

Substances

  • Antidepressive Agents, Second-Generation
  • hydroxybupropion
  • Bupropion
  • Deuterium