This report describes the impact of the implementation of an elective in business and leadership targeted to preclinical medical students. Of the 42 students who completed the elective, 30 (71%) completed the survey. Students reported that they had a better understanding of the U.S. healthcare system (p <.01), had a better understanding of the role of physician-leaders (p <.01), and were more inclined to pursue managerial positions in medicine during their career (p <.01). We determined that an elective in business and leadership in medicine is a valuable addition to the standard undergraduate medical curriculum to enhance medical student exposure to the principles of the business of medicine and physician leadership.