Abstract
Advances in lung transplantation allow the women of childbearing age to consider becoming mothers. When planning to become pregnant, a therapeutic drug management of immunosuppressive drugs and associated therapies is required. It must take into account teratogenic and fetotoxic drugs, as well as pharmacokinetic changes encountered during pregnancy. Increasingly data are currently available on the management of immunosuppressive drugs and associated therapies during pregnancy. We report the case management of drug therapy before and during pregnancy in two patients after a lung or heart-lung transplantation. To prevent the emergence of complications for mother and child, a literature review has been necessary to manage drug therapies of each patient.
© 2015 Société Française de Pharmacologie et de Thérapeutique.
MeSH terms
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Abnormalities, Drug-Induced / prevention & control
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Cesarean Section
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Contraindications
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Cystic Fibrosis / complications
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Female
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Fetal Growth Retardation / etiology
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Fetus / drug effects
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Graft Rejection / prevention & control*
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Heart Transplantation*
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
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Immunosuppressive Agents / adverse effects
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Immunosuppressive Agents / pharmacokinetics
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Immunosuppressive Agents / therapeutic use*
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Infant, Low Birth Weight
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Infant, Newborn
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Infant, Premature
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Lung Transplantation*
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Pravastatin / pharmacokinetics
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Pravastatin / therapeutic use
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Pre-Eclampsia / surgery
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Pregnancy
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Pregnancy Complications / drug therapy*
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Pregnancy Complications / metabolism
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Pregnancy in Diabetics / drug therapy
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Young Adult
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Immunosuppressive Agents
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Pravastatin