Comparative Analysis of Whole-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Hospitalized and Nonhospitalized Patients Identifies Missense Mutations That Might Be Associated with Patient Hospital Admissions in Finland during 2009 to 2014

Polina Mishel; Teija Ojala; Christian Benner; Triin Lakspere; Dmitrii Bychkov; Petri Jalovaara; Laura Kakkola; Hannimari Kallio-Kokko; Anu Kantele; Matti Kankainen; Niina Ikonen; Samuli Ripatti; Ilkka Julkunen; Denis E Kainov

doi:10.1128/genomeA.00676-15

Comparative Analysis of Whole-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Hospitalized and Nonhospitalized Patients Identifies Missense Mutations That Might Be Associated with Patient Hospital Admissions in Finland during 2009 to 2014

Genome Announc. 2015 Jul 30;3(4):e00676-15. doi: 10.1128/genomeA.00676-15.

Authors

Affiliations

¹ The Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
² Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland.
³ Department of Virology, University of Turku, Turku, Finland.
⁴ Helsinki University Hospital Laboratory (HUSLAB), Helsinki, Finland.
⁵ Department of Medicine, University of Helsinki, Helsinki, Finland Inflammation Center, Helsinki University Hospital, Helsinki, Finland.
⁶ National Institute for Health and Welfare (THL), Helsinki, Finland.
⁷ The Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland Department of Public Health, University of Helsinki, Helsinki, Finland Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
⁸ The Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [email protected].

Abstract

Here, we report 40 new whole-genome sequences of influenza A(H1N1)pdm09 viruses isolated from Finnish patients during 2009 to 2014. A preliminary analysis of these and 186 other whole genomes of influenza A(H1N1)pdm09 viruses isolated from hospitalized and nonhospitalized patients during 2009 to 2014 in Finland revealed several viral mutations that might be associated with patient hospitalizations.