Composition and variation analysis of the TCR β-chain CDR3 repertoire in systemic lupus erythematosus using high-throughput sequencing

Mol Immunol. 2015 Oct;67(2 Pt B):455-64. doi: 10.1016/j.molimm.2015.07.012. Epub 2015 Jul 27.

Abstract

The ability of T lymphocytes to mount an immune response against a diverse array of pathogens is primarily conveyed by the amino acid (aa) sequence of the hypervariable complementarity-determining region 3 (CDR3) segments of the T cell receptor (TCR). In this study, we used a combination of multiplex-PCR, Illumina sequencing and IMGT/HighV-QUEST for a standardized analysis of the characteristics and polymorphisms of the T-cell receptor BV complementarity-determining region 3 (TCR BV CDR3) gene in peripheral blood mononuclear cells (PBMCs) from SLE patients and healthy donors (NC). We found the distributions of CDR3, VD indel, and DJ indel lengths to be comparable between the SLE and NC groups. The degree of clonal expansion in the SLE group was significantly greater than in the NC group, and the expression levels of 10 TRβV segments and 6 TRβJ segments were also significantly different in the SLE group. Regarding public T cell responses, 3CDR3 DNA sequences and 4 aa sequences were shared by all SLE patients and may serve as biomarkers for SLE disease risk, diagnosis and/or prognosis.

Keywords: Next generation sequencing; Systemic lupus erythematosus; T cell receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Base Sequence
  • Case-Control Studies
  • Cell Proliferation
  • Clone Cells
  • Complementarity Determining Regions / genetics*
  • Female
  • Gene Frequency
  • Genetic Variation*
  • High-Throughput Nucleotide Sequencing*
  • Humans
  • INDEL Mutation / genetics
  • Lupus Erythematosus, Systemic / genetics*
  • Middle Aged
  • Molecular Sequence Data
  • Receptors, Antigen, T-Cell, alpha-beta / chemistry
  • Receptors, Antigen, T-Cell, alpha-beta / genetics*
  • T-Lymphocytes / pathology
  • Young Adult

Substances

  • Complementarity Determining Regions
  • Receptors, Antigen, T-Cell, alpha-beta