Abstract
Here, we have provided novel insights into the effects of 8-oxodG substitutions on B-Z transitions of CpG dinucleotide DNAs. A combination of different techniques including a CD study, a PAGE analysis, DFT calculations and molecular modeling has been collectively used.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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8-Hydroxy-2'-Deoxyguanosine
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Circular Dichroism
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DNA, Z-Form / chemistry*
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Deoxyguanosine / analogs & derivatives*
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Deoxyguanosine / chemistry
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Humans
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Models, Molecular
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Nucleic Acid Conformation
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Oxidation-Reduction
Substances
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DNA, Z-Form
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8-Hydroxy-2'-Deoxyguanosine
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Deoxyguanosine