Lethal leukoencephalopathy secondary to Tegafur, a 5-fluorouracil prodrug

J Neurol Sci. 2015 Oct 15;357(1-2):326-8. doi: 10.1016/j.jns.2015.07.040. Epub 2015 Jul 29.

Authors

Salvador Sierra¹, Natasha Luquin², Cristina Carrato³

Affiliations

¹ Department of Pharmacology & Systems Therapeutics, Icahn School of Medicine, New York City, NY, United States. Electronic address: [email protected].
² Department of Medical Genomics, Royal Prince Alfred Hospital, Sydney, Australia.
³ Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

PMID: 26242718
DOI: 10.1016/j.jns.2015.07.040

No abstract available

Keywords: 5-Fluorouracil; Tegafur; Toxic leukoencephalopathy.

Publication types

Case Reports
Letter

MeSH terms

Aged
Antimetabolites, Antineoplastic / adverse effects*
Fatal Outcome
Fluorouracil / adverse effects*
Humans
Leukoencephalopathies / chemically induced*
Leukoencephalopathies / diagnosis*
Male
Prodrugs / adverse effects*
Tegafur / adverse effects*

Substances

Antimetabolites, Antineoplastic
Prodrugs
Tegafur
Fluorouracil