[Are treatments with statins that are considered unsuitable really unsuitable?]

Clin Investig Arterioscler. 2015 Jul-Aug;27(4):175-8. doi: 10.1016/j.arteri.2014.10.003. Epub 2014 Dec 24.
[Article in Spanish]

Abstract

In the Catalonian Institute of health there are 2 well-established circumstances for indicating lipid-lowering drug treatment with statins in the primary prevention of ischaemic heart disease. These are, severe hypercholesterolaemia, with a low density lipoprotein cholesterol equal to or greater than 240mg/dL, or above 130mg/dL when the coronary risk is equal to or greater than 10% at 10 years. There are data that suggest that these 2 criteria are not the only ones used in routine clinical practice, as such that the majority of patients to whom it is indicated, do not meet either of these 2 conditions. This study aims to determine the characteristics of the patients when statins are indicated outside the aforementioned circumstances. It is concluded that around 40% of patients have clinical characteristics that could justify the treatment. The level of suitability could not be established in about 33% of the patients, due to not being able to determine the coronary risk.

Keywords: Estatinas; HMG-CoA; Hipercolesterolemia; Hydroxymethylglutaryl-CoA reductase inhibitors; Hypercholesterolemia; Inhibidores de la Hidroximetilglutaril-CoA reductasa; Riesgo; Risk; Statins.

MeSH terms

  • Anticholesteremic Agents / therapeutic use
  • Cholesterol, LDL / administration & dosage
  • Cholesterol, LDL / blood
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Hypercholesterolemia / drug therapy*
  • Myocardial Ischemia / prevention & control*
  • Primary Prevention
  • Risk Factors

Substances

  • Anticholesteremic Agents
  • Cholesterol, LDL
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors