Comments on Bu et al. "P16(INK₄a) overexpression and survival in osteosarcoma patients: a meta analysis"

Int J Clin Exp Pathol. 2015 Jun 1;8(6):7617-8. eCollection 2015.

Abstract

Recently, we read the article "P16(INK4a) overexpression and survival in osteosarcoma patients: a meta analysis" by Jie Bu and his colleagues, published in the recent issue of International Journal Of Experimental Pathology. This research performed a meta-analysis to uncover the role of P16(INK4a) expression in overall survival rate in patients with osteosarcoma. The investigators concluded as follows: (i) the pateints with overexpression of P16(INK4a) had a longer overall survival rate than that with loss expression of P16(INK4a); (ii) P16(INK4a) was an effective biomarker of prognosis in patients with osteosarcoma.The findings are valubale and encouraging. However, some flaws and imperfections rooted in this work.

Keywords: Osteosarcoma; P16INK4a; meta-analysis.

Publication types

  • Comment

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Bone Neoplasms / chemistry*
  • Cyclin-Dependent Kinase Inhibitor p16 / analysis*
  • Humans
  • Osteosarcoma / chemistry*

Substances

  • Biomarkers, Tumor
  • Cyclin-Dependent Kinase Inhibitor p16