Encephalitozoon hellem in a patient with CD4+ T-cell prolymphocytic leukemia: case report and genomic identification

Gilles Nevez; Solène Le Gal; Dorothée Quinio; Jean-Christophe Ianotto; Christian Berthou; Samia Hamane; Claudine Sarfati; Jean Menotti

doi:10.1016/j.diagmicrobio.2015.07.015

Encephalitozoon hellem in a patient with CD4+ T-cell prolymphocytic leukemia: case report and genomic identification

Diagn Microbiol Infect Dis. 2015 Nov;83(3):245-7. doi: 10.1016/j.diagmicrobio.2015.07.015. Epub 2015 Jul 26.

Authors

Gilles Nevez¹, Solène Le Gal², Dorothée Quinio³, Jean-Christophe Ianotto⁴, Christian Berthou⁴, Samia Hamane⁵, Claudine Sarfati⁵, Jean Menotti⁵

Affiliations

¹ University of Brest, LUBEM EA 3882, SFR 148, and Laboratory of Parasitology and Mycology, Brest University Hospital, Brest, France. Electronic address: [email protected].
² University of Brest, LUBEM EA 3882, SFR 148, and Laboratory of Parasitology and Mycology, Brest University Hospital, Brest, France. Electronic address: [email protected].
³ University of Brest, LUBEM EA 3882, SFR 148, and Laboratory of Parasitology and Mycology, Brest University Hospital, Brest, France.
⁴ University of Brest, EA 2216, SFR 148, Institute of Oncology and Hematology, Brest University Hospital, Brest, France.
⁵ Laboratory of Parasitology and Mycology, Saint-Louis hospital, AP-HP and Paris-Diderot University, Sorbonne Paris Cité, Paris, France.

PMID: 26299583
DOI: 10.1016/j.diagmicrobio.2015.07.015

Abstract

Five cases of microsporidioses among leukemic patients, 4 in myeloid-leukemic patients and 1 in a chronic lymphocytic leukemia, have been described until now. We report a case of microsporidiosis and the genomic identification of Encephalitozoon hellem in a patient with CD4(+) T-cell prolymphocytic leukemia.

Keywords: Encephalitozoon hellem; Leukemic patient.

Publication types

Case Reports

MeSH terms

Aged
CD4-Positive T-Lymphocytes / pathology*
DNA, Fungal / chemistry
DNA, Fungal / genetics
DNA, Ribosomal / chemistry
DNA, Ribosomal / genetics
Encephalitozoon / isolation & purification*
Encephalitozoonosis / diagnosis*
Encephalitozoonosis / microbiology
Female
Genes, rRNA
Humans
Leukemia, Prolymphocytic, T-Cell / complications*
Molecular Sequence Data
RNA, Fungal / genetics
RNA, Ribosomal, 18S / genetics
Sequence Analysis, DNA

Substances

DNA, Fungal
DNA, Ribosomal
RNA, Fungal
RNA, Ribosomal, 18S