Monocyte-Derived Suppressor Cells in Transplantation

Curr Transplant Rep. 2015;2(2):176-183. doi: 10.1007/s40472-015-0054-9.

Abstract

Myeloid-derived suppressor cells (MDSC) are cells of myeloid origin with enhanced suppressive function. They are negative regulators of the immune responses and comprise a heterogeneous mixture of immunosuppressive cells of monocytic (M-MDSC) and granulocytic (G-MDSC) origin. A more recent nomenclature proposes the term "suppressive monocyte derived cells" (suppressive MCs) to define CSF1/CSF2-dependent mouse suppressor cells that develop from common monocyte progenitors (cMoPs) after birth. Here, we review the literature about monocytic-derived cells with demonstrated suppressor function in vitro and in vivo within the context of solid organ transplantation.

Keywords: Immune regulation; MDSC; Suppressor MCs; Transplantation.

Publication types

  • Review