A Long-Distance Chromatin Affair

Annette Denker; Wouter de Laat

doi:10.1016/j.cell.2015.08.022

A Long-Distance Chromatin Affair

Cell. 2015 Aug 27;162(5):942-3. doi: 10.1016/j.cell.2015.08.022.

Authors

Annette Denker¹, Wouter de Laat²

Affiliations

¹ Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands.
² Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands. Electronic address: [email protected].

PMID: 26317462
DOI: 10.1016/j.cell.2015.08.022

Abstract

Changes in transcription factor binding sequences result in correlated changes in chromatin composition locally and at sites hundreds of kilobases away. New studies demonstrate that this concordance is mediated via spatial chromatin interactions that constitute regulatory modules of the human genome.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Chromatin / chemistry*
Chromatin / metabolism*
Chromosomes, Human / metabolism*
Female
Gene Expression Regulation*
Genetic Variation*
Genome, Human*
Human Genome Project*
Humans
Male

Substances

Chromatin