IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus

Federica Facciotti; Nicola Gagliani; Barbara Häringer; Johanna Sophie Alfen; Alessandra Penatti; Stefano Maglie; Moira Paroni; Andrea Iseppon; Monica Moro; Maria Cristina Crosti; Katharina Stölzel; Chiara Romagnani; Gabriella Moroni; Francesca Ingegnoli; Sara Torretta; Lorenzo Pignataro; Andrea Annoni; Fabio Russo; Massimiliano Pagani; Sergio Abrignani; Pierluigi Meroni; Richard Flavell; Jens Geginat

doi:10.1016/j.jaci.2015.06.044

IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus

J Allergy Clin Immunol. 2016 Jan;137(1):318-321.e5. doi: 10.1016/j.jaci.2015.06.044. Epub 2015 Aug 25.

Authors

Federica Facciotti¹, Nicola Gagliani², Barbara Häringer³, Johanna Sophie Alfen⁴, Alessandra Penatti⁵, Stefano Maglie¹, Moira Paroni¹, Andrea Iseppon², Monica Moro¹, Maria Cristina Crosti¹, Katharina Stölzel⁶, Chiara Romagnani⁷, Gabriella Moroni⁸, Francesca Ingegnoli⁹, Sara Torretta¹⁰, Lorenzo Pignataro¹⁰, Andrea Annoni¹¹, Fabio Russo¹¹, Massimiliano Pagani¹², Sergio Abrignani¹³, Pierluigi Meroni⁵, Richard Flavell¹⁴, Jens Geginat¹⁵

Affiliations

¹ INGM-National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi", Milan, Italy.
² Department of Immunobiology, Yale University, New Haven, Conn.
³ DRFZ-German Rheumatology Research Institute, Berlin, Germany; Medical Department, Division of Rheumatology and Clinical Immunology, Charité Universitätsmedizin, Berlin, Germany.
⁴ INGM-National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi", Milan, Italy; Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, University of Milan, Milan, Italy.
⁵ DISCCO-Department of Clinical Science and Community Health, Universitá degli Studi di Milano, Milan, Italy.
⁶ Medical Department, Division of Rheumatology and Clinical Immunology, Charité Universitätsmedizin, Berlin, Germany.
⁷ DRFZ-German Rheumatology Research Institute, Berlin, Germany.
⁸ Unità operativa di Nefrologia e Dialisi, Milan, Italy.
⁹ Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, University of Milan, Milan, Italy.
¹⁰ Otorinolaringoiatria Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
¹¹ San Raffaele Telethon Institute for Gene Therapy, and the Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
¹² INGM-National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi", Milan, Italy; Department of Medical Biotechnology and Translational Medicine, Universitá degli Studi di Milano, Milan, Italy.
¹³ INGM-National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi", Milan, Italy; DISCCO-Department of Clinical Science and Community Health, Universitá degli Studi di Milano, Milan, Italy.
¹⁴ Department of Immunobiology, Yale University, New Haven, Conn; Howard Hughes Medical Institute School of Medicine, Yale University, New Haven, Conn.
¹⁵ INGM-National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi", Milan, Italy. Electronic address: [email protected].

PMID: 26318071
DOI: 10.1016/j.jaci.2015.06.044

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Animals
B-Lymphocytes / immunology*
Female
Forkhead Transcription Factors / immunology
Humans
Interleukin-10 / immunology*
Leukocytes, Mononuclear / immunology
Lupus Erythematosus, Systemic / immunology*
Male
Mice, Inbred C57BL
Mice, Transgenic
Middle Aged
Palatine Tonsil / cytology
T-Lymphocytes, Regulatory / immunology*
Young Adult

Substances

FOXP3 protein, human
Forkhead Transcription Factors
IL10 protein, human
Interleukin-10