Clinical, hemodynamic, and angiographic data were examined in 53 patients who underwent catheterization within 6 months of a documented first acute transmural myocardial infarction. The patients were divided according to the presence (23 patients) or absence (30 patients) of angina pectoris 1 month after infarction (group I and group II). Group I patients had more severe coronary artery disease and a greater prevalence of multivessel disease than group II patients. Partial preservation of segmental wall function in group I was related to the presence of collateral vessels. In patients with single vessel disease, the incidence of spontaneous recanalization of the infarct-related artery was higher in group I as compared with that in group II. It is concluded that angina pectoris after myocardial infarction suggests multivessel disease or infarct-related artery recanalization. Coronary arteriography may be advised in order to select adequate therapeutic interventions and improve prognosis in these patients.