The Value of MicroRNA-155 as a Prognostic Factor for Survival in Non-Small Cell Lung Cancer: A Meta-Analysis

PLoS One. 2015 Aug 31;10(8):e0136889. doi: 10.1371/journal.pone.0136889. eCollection 2015.

Abstract

Background: Recent studies have shown that miR-155 play a positive role in the development of carcinoma. This meta-analysis aimed to identify the role of miR-155 in the survival of non-small cell lung cancer patients.

Methodology: Eligible studies were identified through database searches. Relevant data were extracted from each eligible study to assess the correlation between miR-155 expression and survival in lung carcinoma patients. The hazard ratios (HRs) and 95% confidence intervals (CIs) of the patients' outcomes in relation to miR-155 were calculated. A total of 6 studies were included for this meta-analysis. For overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), and cancer-specific survival (CSS), the combined HRs and 95% CIs were not statistically significant. Additionally, in Asian and America subgroups, greater expression levels of miR-155 were related to poor prognoses for lung cancer (HR 1.71 95% CI: 1.22-2.40, P = 0.002, HR 2.35 95% CI: 1.42-3.89 P = 0.001), while no significant relationship was present in a Europe subgroup (HR 0.75 95%CI: 0.27-2.10, P = 0.587).

Conclusions: These results suggest that miR-155 expression is not significantly related to non-small cell lung cancer patients except in patients from Asian and America.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People / genetics
  • Carcinoma / genetics
  • Carcinoma / mortality
  • Carcinoma / pathology
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Carcinoma, Non-Small-Cell Lung / mortality*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Disease-Free Survival
  • Europe
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / mortality*
  • Lung Neoplasms / pathology
  • MicroRNAs / genetics*
  • Prognosis
  • Proportional Hazards Models

Substances

  • MIRN155 microRNA, human
  • MicroRNAs

Grants and funding

This work was supported by NSFC (Natural Science Foundation of China) (81360351), Start-Up Fund for Doctor of Zunyi Medical University and the Department of Science and Technology of Guizhou Province (Grant No. Qian Ke He SY[2013] 3003). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.