Abstract
Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminobutyrates / chemistry
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Ionophores / chemistry*
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Ionophores / pharmacology*
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Lipid Bilayers / chemistry
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Lipid Bilayers / metabolism
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Models, Molecular
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Molecular Conformation
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Peptaibols / chemistry*
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Peptidomimetics / chemistry*
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Peptidomimetics / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Aminobutyrates
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Ionophores
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Lipid Bilayers
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Peptaibols
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Peptidomimetics
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alpha-aminobutyric acid