Abstract
Multifocal fibrosclerosis is the term used to represent a combination of similar fibrous lesions occurring at different anatomical sites. We herein report a hypertrophic pachymeningitis patient with a soft tissue mass around the thoracic vertebral bodies. A histopathological analysis of the biopsied tissues from both lesions showed dense fibrosis and a marked infiltration of lymphocytes and plasma cells, which lead to the diagnosis of multifocal fibrosclerosis. This pathological condition closely resembles that of IgG4-related disease and is a very rare combination of manifestations. Our case suggests that hypertrophic pachymeningitis patients need to also undergo a whole body examination.
MeSH terms
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Aged
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Anti-Inflammatory Agents / therapeutic use
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Humans
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Hypertrophy / diagnosis
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Immunosuppressive Agents / therapeutic use
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Male
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Meningitis / complications*
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Meningitis / diagnosis*
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Meningitis / drug therapy
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Meningitis / pathology
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Methylprednisolone / therapeutic use
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Plasma Cells / pathology
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Retroperitoneal Fibrosis / complications
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Retroperitoneal Fibrosis / congenital*
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Retroperitoneal Fibrosis / diagnosis
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Retroperitoneal Fibrosis / drug therapy
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Retroperitoneal Fibrosis / pathology
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Tacrolimus / therapeutic use
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Thoracic Vertebrae / pathology
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Treatment Outcome
Substances
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Anti-Inflammatory Agents
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Immunosuppressive Agents
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Tacrolimus
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Methylprednisolone
Supplementary concepts
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Multifocal fibrosclerosis