Abstract
The administration of a dopamine antagonist, chlorpromazine, and two opiates, morphine and methadone, resulted in a significant rise in serum PRL within 90-150 min. Prior administration of dopamine receptor agonists (apomorphine, levodopa, aand bromocriptine) blocked this effect. In contrast, cyproheptadine, a serotonin antagonist, did not. We suggest that the opiates induce hyperprolactinemia in man via dopamine receptor blockade.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apomorphine
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Bromocriptine
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Chlorpromazine / therapeutic use*
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Cyproheptadine
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Heroin Dependence / drug therapy
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Humans
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Kinetics
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Levodopa
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Methadone / therapeutic use*
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Morphine / therapeutic use*
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Prolactin / blood*
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Receptors, Dopamine / metabolism*
Substances
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Receptors, Dopamine
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Cyproheptadine
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Bromocriptine
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Levodopa
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Morphine
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Prolactin
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Apomorphine
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Chlorpromazine
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Methadone