Nanoporous Metal-Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide

Junling Guo; Xiaowei Wang; Darren C Henstridge; Joseph J Richardson; Jiwei Cui; Arpeeta Sharma; Mark A Febbraio; Karlheinz Peter; Judy B de Haan; Christoph E Hagemeyer; Frank Caruso

doi:10.1002/adhm.201500528

Nanoporous Metal-Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide

Adv Healthc Mater. 2015 Oct;4(14):2170-2175. doi: 10.1002/adhm.201500528. Epub 2015 Sep 1.

Authors

Junling Guo¹, Xiaowei Wang^{2

3}, Darren C Henstridge⁴, Joseph J Richardson¹, Jiwei Cui¹, Arpeeta Sharma⁵, Mark A Febbraio⁴, Karlheinz Peter^{2

3

6}, Judy B de Haan⁵, Christoph E Hagemeyer^{3

6

7}, Frank Caruso¹

Affiliations

¹ ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
² Atherothrombosis and Vascular Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
³ Central Clinical School, Monash University, Melbourne, Victoria, 3004, Australia.
⁴ Cellular and Molecular Metabolism, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
⁵ Oxidative Stress, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.
⁶ School of Applied Sciences, RMIT University, Melbourne, Victoria, 3000, Australia.
⁷ Vascular Biotechnology, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia.

PMID: 26331367
DOI: 10.1002/adhm.201500528

Abstract

Nanoporous metal-phenolic particles are fabricated through the nanostructural replication of dense Fe^III -TA complexes in nanoporous CaCO₃ template particles. The particles have potential for the diagnostic detection of endogenous levels of H₂ O₂ ex vivo and in vivo by ultrasound imaging, which is based on the catalytic activity of the coordinated Fe³⁺ in the particles to break down H₂ O₂ to O₂ microbubbles.

Keywords: hydrogen peroxide; metal-phenolic particles; ultrasound imaging.