Woringer-Kolopp (Pagetoid Reticulosis) disease successful response to bexarotene gel

Dermatol Ther. 2016 Jan-Feb;29(1):28-31. doi: 10.1111/dth.12281. Epub 2015 Sep 2.

Abstract

Woringer-Kolopp (WK) is a rare subtype of cutaneous T-cell lymphoma (CTCL) with limited treatment options. Bexarotene gel is a topical retinoid used in the treatment of CTCL. This report describes three female patients (mean age 66 years) with WK disease who had an effective treatment response to bexarotene 1% gel. This treatment could provide a safe alternative to other current treatment modalities which have higher risks of potential adverse effects and lack of access to other conventional treatments such as light therapy.

Keywords: inflammatory disorders; neoplasms-malignant; therapy-topical.

Publication types

  • Case Reports

MeSH terms

  • Administration, Cutaneous
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents / administration & dosage*
  • Bexarotene
  • Biomarkers, Tumor / analysis
  • Biopsy
  • Female
  • Gels
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Pagetoid Reticulosis / chemistry
  • Pagetoid Reticulosis / drug therapy*
  • Pagetoid Reticulosis / pathology
  • Remission Induction
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology
  • Tetrahydronaphthalenes / administration & dosage*
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Gels
  • Tetrahydronaphthalenes
  • Bexarotene