Control of Mesh Size and Modulus by Kinetically Dependent Cross-Linking in Hydrogels

Zachary K Zander; Geng Hua; Clinton G Wiener; Bryan D Vogt; Matthew L Becker

doi:10.1002/adma.201501822

Control of Mesh Size and Modulus by Kinetically Dependent Cross-Linking in Hydrogels

Adv Mater. 2015 Oct 28;27(40):6283-8. doi: 10.1002/adma.201501822. Epub 2015 Aug 31.

Authors

Zachary K Zander¹, Geng Hua¹, Clinton G Wiener², Bryan D Vogt², Matthew L Becker¹

Affiliations

¹ Department of Polymer Science, The University of Akron, Akron, OH, 44325, USA.
² Department of Polymer Engineering, The University of Akron, Akron, OH, 44325, USA.

Abstract

Kinetically controlled cross-linking processes produce mechanically distinguishable hydrogels using identical precursor chemistry. The oxime ligation demonstrates tunable reaction kinetics with pH and buffer strength, which induce changes in the structural features of hydrogels and determine their mechanical properties. Small-angle neutron scattering and swelling studies provide an insight into how structural properties correlate with mechanical properties for this hydrogel system.

Keywords: hydrogels; microstructures; structure-property relationships; tissue engineering.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Hydrogels / chemistry*
Hydrogen-Ion Concentration
Kinetics
Materials Testing
Molecular Structure
Neutron Diffraction
Rheology
Scattering, Small Angle

Substances

Hydrogels

Abstract

Publication types

MeSH terms

Substances

Grants and funding