Improving the performance of J-modulated ADEQUATE experiments through homonuclear decoupling and non-uniform sampling

Homonuclear ¹³ C-¹³ C couplings at natural abundance can be measured using the J-modulated Adequate DoublE QUAntumTransfer Experiment (ADEQUATE) experiment. To somewhat ameliorate F₁ digitization requirements, a scaling factor was incorporated into the original pulse sequence. Non-uniform sampling provides an obvious avenue to further facilitate the acquisition of ¹ J_CC and ⁿ J_CC homonuclear coupling constant data. We introduce homonuclear decoupling (HD) analogous to that described for the 1,1-HD-ADEQUATE and 1,n-HD-ADEQUATE experiments and evaluate the combination of non-uniform sampling and HD on the acquisition of both ¹ J_CC and ⁿ J_CC homonuclear ¹³ C-¹³ C coupling constants using ibuprofen as a model compound. Copyright © 2015 John Wiley & Sons, Ltd.